Senescence Therapy Program

Senescence is an aging process in which a cell permanently stops dividing yet does not die. This occurs when the cell experiences various stressors that lead to the accumulation of damaged DNA. By entering into senescence mode, this prevents further damage by halting reproduction.

While not fully dormant, senescent cells can accumulate in different organs and tissues due to aging or other health concerns like obesity and metabolic diseases. These cells lead to dysfunction and give rise to inflammation-inducing cytokines, chemokines, and proteases known as the senescence-associated secretory phenotype (SASP).

Through senescence, aging and age-related diseases occur. This same process causes other cells to become aged as well; these may eventually develop into cancer due to their damaged DNA. Over time, the accumulation of senescent cells can create a domino effect throughout our bodies – leading us closer to illness or disease, like cancer.

Exercising has also been beneficial for regulating hormones that affect aging, such as insulin and growth hormones. This can lead to better overall health and decreased inflammation in the body. Additionally, regular physical activity boosts circulation and builds strength which helps keep our bodies running efficiently.

Senescence therapy reduces the number of senescent cells in the body to slow down aging and certain age-related diseases. Complimenting senescence therapy with lifestyle changes such as eating healthy, exercising regularly, avoiding smoking, and drinking alcohol, getting adequate sleep, and reducing stress can also help reverse or prevent the accumulation of senescent cells.

Eating foods high in antioxidants and omega-3 fatty acids (such as salmon, walnuts, and flaxseeds) can reduce inflammation throughout the body and decrease the number of senescent cells present.

Exercising has also been beneficial for regulating hormones that affect aging, such as insulin and growth hormones. This can lead to better overall health and decreased inflammation in the body. Additionally, regular physical activity boosts circulation and builds strength which helps keep our bodies running efficiently.

Studies conducted on humans have uncovered that senolytic medications, which wipe out senescent cells, can eradicate these potentially harmful cells. Early data revealed Dasatinib and Quercetin to reduce the number of senescent fat cells within 11 days while simultaneously lessening cellular markers associated with aging. To detect and track levels of senescence, β-galactosidase activity and adipocyte progenitors (akin to stem cells) are tested in blood samples.

The cancer drug Sprycel (Dasatinib) treats specific types of leukemia in adults and children, inducing apoptosis through tyrosine kinase inhibition. Quercetin, a flavonoid with antioxidative and anti-inflammatory properties naturally found as a nutritional supplement, further reduces senescent cells, which are attributed to numerous age-related conditions. This combination has proven effective at targeting these cells for destruction resulting in improved health outcomes.

Initially developed as an immunosuppressant for organ transplant recipients, Rapamycin impedes the mTOR pathway. This is a key factor in allowing autophagy – cell recycling – to occur within human cells. When a patient receives Rapamycin, it inhibits the mTOR pathway and permits cellular self-recycling to commence without any disruptions.

Studies have suggested that those who take senolytics may reap multiple benefits, including the destruction of senescent cells and a reduction in age-related markers. Furthermore, it has been proposed that taking senolytics could slow cell proliferation, decelerate aging, and reduce the risk for various age-related diseases.

Not only may these substances help to counteract spinal disc deterioration related to aging, but they might also reduce metabolic disease and control the effects of diabetes. Studies show that taking senolytics could also lower inflammatory markers in the bloodstream while promoting adipogenesis–the process by which new fat cells are formed.

Dasatinib may lead to temporary immunosuppression; therefore, all patients must receive assistance and supervision from a qualified physician. Your right to make decisions is based on personal beliefs, so our dedicated physicians will provide comprehensive information regarding the potential risks and benefits of each treatment option available for you to decide confidently.

Quercetin and Dasatinib may cause some mild side effects such as flu-like symptoms, fatigue, headache, and diarrhea. On the other hand, more serious side effects of Dasatinib include anemia, rash & low blood cell counts, as well as heart failure & pulmonary edema -all of which are more likely if you take it on a daily basis. In addition to that, there is also an increased risk of bleeding disorders or prolonged QT syndrome.

Side effects of Quercetin and Dasatinib include mild flu symptoms, diarrhea, headache, fatigue, allergic reaction. In addition, Dasatinib may cause low blood cell counts, anemia, rash, and diarrhea. It may also cause serious side effects such as bleeding, pulmonary edema, heart failure, and prolonged QT syndrome. These potential side effects are more common when Dasatinib is used daily.

We are prescribing for you a 3-month plan, with the option to repeat this same plan for a total of 6 months.

You will take a medication called Sirolimus, also known as Rapamycin. Sirolimus has been shown to delay the onset of several age-related diseases, such as cognitive decline, cancer, heart disease and immune system decline. Sirolimus inhibits the activity of TORC1—a protein complex that acts as a sensor for cellular nutrients and energy, and regulates protein synthesis. The increased destruction of damaged cells which is activated by TORC1 is essential for sirolimus’s role in extending lifespan.

You will take 1 capsule by mouth once a week for 10 weeks.

During this phase of the therapy, you will take a determined number of capsules containing Quercetin 400mg, an antioxidant supplement, and Dasatinib 30mgs, a mild chemotherapy agent.

The number of pills is determined by your weight.

• 100 lbs or less – 3 Capsules
• 165 lbs – 6 Capsules
• 220 lbs  – 8 Capsules
• 275 lbs – 10 Capsules
• 330 lbs or higher – 12 Capsules

You only take the capsules once a week for a total of 2 consecutive weeks.

As always, if you have any questions, concerns or comments, please direct them to your Client Liaison.

Your feedback is always appreciated.