Plasma Exchange
Inuspheresis® and Advanced Therapeutic Plasma Exchange
Inuspheresis® is a specialized form of therapeutic apheresis designed to filter pathologically relevant substances directly from blood plasma using targeted double-filtration technology. The procedure separates plasma from cellular blood components, passes it through specialized intelligent membranes to scrub targeted inflammatory proteins, heavy metals, environmental toxins, and autoantibodies, and then returns the purified plasma back to the patient.
To learn about Inuspheresis, schedule a free telehealth appointment.
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Inuspheresis® vs. Therapeutic Plasma Exchange
Both Inuspheresis® and Therapeutic Plasma Exchange (TPE) fall under the broader umbrella of extracorporeal blood purification therapies. While both aim to remove pathogenic substances from circulation to reduce systemic inflammation, they differ fundamentally in how they handle liquid plasma.
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| Feature | Inuspheresis® | Therapeutic Plasma Exchange (TPE) |
|---|---|---|
| Primary Mechanism | Selective double-filtration: Filters and returns the original plasma, which only removes substances with specific molecular weights. | Complete plasma replacement: Removes all harmful substances if they exist in the plasma, regardless of molecular weight, and replaces with albumin. |
| Type of Replacement Fluid | None: Patient retains their own liquid plasma. | High: Requires replacement with human 5% albumin. |
| US Availability | Unavailable in mainstream US clinical practice. | Widely accessible across medical centers and specialized US clinics. |
| Clinical Footprint | Primarily offered in specialized European longevity & functional clinics. | Decades of US ASFA-guided protocols and off-label use for other modalities. |
Advantages of Therapeutic Plasma Exchange
Comprehensive Pathogen Removal
Since TPE completely removes the patient’s existing plasma and replaces it with albumin, after which within a few days the body replaces the albumin with the patient’s own new plasma, it guarantees the complete elimination of circulating inflammatory mediators, autoantibodies, cytokines, and microclots which exist within the patient’s plasma volume. Double-filtration methods are constrained by filter pore sizes, whereas TPE provides a complete replacement of the intravascular fluid environment.
Decades of Clinical Validation
TPE is backed by extensive clinical literature and formal guidelines established by the American Society for Apheresis (ASFA). Indications, volume calculations, and safety parameters for TPE are standardized globally, whereas clinical evidence for Inuspheresis® and similar procedures generally relies heavily on proprietary observational data and smaller private clinic cohorts.
US Accessibility & Regulatory Approval
TPE is a well-established, FDA-approved for certain disease states, readily available in hospitals, academic medical centers, and specialized outpatient clinics across the United States. In contrast, Inuspheresis® is primarily restricted to proprietary clinics in Europe (most notably Germany and Switzerland), making TPE far more accessible without the immense burden and expense of international travel.
Lower Risk of Filter Membrane Clogging
Double-filtration procedures like Inuspheresis® rely on cascading membrane filters that often saturate during high-viscosity or high-protein loads, requiring session pauses or membrane swaps. TPE is not affected by this limitation because it is a complete removal of the plasma.
Schedule a Free Appointment
Learn more about the differences between Inuspheresis and therapeutic plasma exchange. Schedule a free call and learn more from one of our specialized physicians.
- Learn the unique differences between Inuspheresis and Advanced Serial Plasma Exchange protocols.
- Review your history and goals to find out if you are a good candidate for plasma exchange and which method is right for you.
- Find out how both plasma exchange methods can help reduce toxins, inflammatory proteins, and chronic infections to support your brain, immune, and metabolic health.
- Determine which protocols will work best for you and how to customize the procedure for your body and goals.
- Protocol pricing: the price for each protocol varies depending on your goals and personalized health needs. Our physicians can give you options from a 30 minute virtual discussion.
- The virtual doctor’s appointment is free. No insurance is required.
Our Personalized Approach to Plasma Exchange
PlasmaXchange is a patent pending TPE procedure that can be more effective than other plasma filtration methods.
Personalized Plan
Plasma exchange adds advanced diagnostics, tracks toxin levels & biomarker changes, and uses those results to personalize the plasma exchange plan.
Multi-modal Program
Beyond TPE, Plasma exchange bundles IV nutrient therapy after each session, daily protein-powder supplementation, and lifestyle guidance to prevent re-toxification.
Specialized Physicians
Our physicians specialize in TPE and use their focused experience to design highly individualized plans that account for complex conditions and maximize the removal of disease-causing substances.
Advanced TPE Patient Case Studies
Hear stories from patients who received the Advanced Serial TPE procedures.
Advanced Serial TPE Pricing
MDLifespan offers a variety of Advanced Serial TPE protocols designed to address specific health challenges and wellness goals. Each program is personalized to your unique clinical needs, utilizing targeted diagnostics and nutrient therapies to maximize effectiveness for your individual scenario.
Pricing for these programs starts at $5,995. To get a detailed recommendation and specific pricing for your health goals, please schedule a 30-minute appointment with an MDLifespan doctor.
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| Protocol Name | Targeted Conditions & Applications | TPE Sessions | IV Nutrient Therapy |
|---|---|---|---|
| MDL Mold | Mold toxicity, CIRS, chronic fatigue, mycotoxin-related brain fog. | 3 or 5 | MDL Clean |
| MDL Toxin | Heavy metals, pesticides, PFAS (forever chemicals), microplastics. | 3 or 5 | MDL Clean |
| MDL Immunity | Immunity resilience, autoimmune (Arthritis, MS), Lyme disease, chronic infections, Mast Cell (MCAS). | 3 or 5 | MDL Clean |
| MDL Brain | Alzheimer’s, ALS, neuroinflammation, memory loss, brain fog. | 5 | MDL Clean |
| MDL Heart | Systemic inflammation, cardiovascular disease, arterial health. | 5 | MDL Clean |
| MDL Longevity | Slow biological aging, high oxidative stress, high biological age markers, general vitality. | 3 or 5 | MDL Clean |
| MDL Cancer | Immune support during recovery, lowering markers tied to progression. | 3 | MDL Clean |
| MDL Baby | Clearing toxic burden before pregnancy for optimal fetal health. | 2 | MDL Clean |
| MDL Basic | Maintenance for healthy individuals, “oil change” for the blood. | 1 – 3 | None |
Each protocol is customized to your specific needs to ensure we maximize effectiveness. By tailoring the number of sessions and the nutrient therapies to your biology, we can more effectively target the root causes of your health concerns. To receive your personalized protocol options and pricing, please schedule a 30-min appointment with our doctors.