PlasmaXchange
Lyme Disease Symptoms and Therapeutic Plasma Exchange
Lyme disease is caused by bacteria from tick bites that spread throughout the body which can trigger severe joint inflammation or pain, neurological impairment, heart issues, and severe fatigue. Therapeutic plasma exchange helps reduce Lyme disease symptoms by filtering the blood to remove the bacteria, inflammatory toxins, and harmful antibodies that cause persistent symptoms even when antibiotics fail.
To learn more about these symptoms, schedule a consult.
Symptoms From Lyme Disease
Lyme disease is a multisystemic illness caused by the bacterium Borrelia burgdorferi.
Because the bacteria can migrate through the bloodstream to almost any tissue in the body, the symptoms are diverse and often mimic other conditions.
- Persistent Fatigue: This is often described as a “heavy” exhaustion that does not improve with rest. It is caused by the body’s massive expenditure of energy as the immune system remains in a state of chronic activation to fight the persistent infection.
- Joint Pain and Swelling (Lyme Arthritis): Patients often experience migratory pain that moves from one joint to another, commonly affecting the knees. This happens because the bacteria have a preference for connective tissues, leading to direct inflammation of the synovial lining.
- Cognitive Dysfunction and Brain Fog: Symptoms include memory loss, difficulty concentrating, and “word-finding” struggles. This occurs due to neuroinflammation which disrupts normal neurotransmitter signaling.
- Neurological Impairments: This can manifest as facial palsy (Bell’s palsy), numbness, or tingling in the extremities (peripheral neuropathy). The bacteria can physically infiltrate nerve sheaths, causing direct damage and inflammatory “short-circuiting” of nerve signals.
- Heart Palpitations (Lyme Carditis): Some patients experience a racing heart or lightheadedness. This occurs when the bacteria enter the heart tissues and interfere with the electrical impulses that coordinate the heartbeat, potentially leading to a “heart block.”
- Bull’s-Eye Rash (Erythema Migrans): A circular, expanding red rash often appears at the site of the tick bite. This is a localized inflammatory reaction as the bacteria begin to multiply and move outward through the skin.
Plasma Exchange Removes Bacteria and Antibodies from Lyme
Therapeutic plasma exchange is a medical procedure that filters out contaminated plasma containing Lyme pathogens and toxins. It then combines healthy blood cells with a new customized saline, albumin, and vitamin plasma solution. This process physically removes harmful substances like immune complexes and inflammatory markers. This helps to reset immune system activity and reduce chronic pain or neurological symptoms caused by the disease.
Plasma exchange helps remove harmful substances from Lyme disease:
- Bacterial Debris and Biofilm Fragments: Parts of the Borrelia bacteria and their protective coatings that keep the immune system in a state of constant alarm.
- Autoantibodies: Misguided antibodies produced by the body that mistakenly attack its own nerves and connective tissues after being triggered by the infection.
- Immune Complexes: Clumps of Lyme antigens and antibodies that circulate and deposit in the joints and brain, causing persistent inflammation and brain fog.
- Inflammatory Cytokines: Proteins that drive systemic inflammation, contributing to the constant fatigue and widespread muscle aches.
- Neurotoxins: Metabolic waste products from the bacteria that can interfere with nerve signaling and cognitive function.
By removing the contaminated plasma, this procedure lowers the concentration of these harmful components in the body. This naturally strengthens the immune system and alleviates the symptoms of chronic or neurological Lyme disease. This method can be effective even when antibiotics fail.

Speak to a Physician
Learn more about TPE, the different protocols, and pricing. Fill out the questionnaire and learn more from one of our specialized physicians.
- Review your history and goals to find out if you are a good candidate for therapeutic plasma exchange (TPE).
- Find out how TPE can help reduce toxins, inflammatory proteins, and chronic infections to support your brain, immune, and metabolic health.
- Learn what’s unique about MDLifespan patent-pending plasma exchange protocols.
- Determine which protocols will work best for you and how to customize the procedure for your body and goals.
- Protocol pricing: the price for each protocol varies depending on your goals and personalized health needs. Our physicians can give you options from a 30 minute discussion.
Step 1 of 6
Plasma Exchange Relieves Lyme Symptoms
PlasmaXchange is a patent pending TPE procedure that can be more effective than traditional plasma exchange.
Personalized Plan
PlasmaXchange adds advanced diagnostics, tracks toxin levels & biomarker changes, and uses those results to personalize the plasma exchange plan.
Multi-modal Program
Beyond TPE, PlasmaXchange bundles IV nutrient therapy after each session, daily protein-powder supplementation, and lifestyle guidance to prevent re-toxification.
Specialized Physicians
Our physicians specialize in TPE and use their focused experience to design highly individualized plans that account for complex conditions and maximize the removal of disease-causing substances.
PlasmaXChange Patient Case Studies
Hear stories from patients who received the personalized PlasmaXChange TPE procedure.
About Dr. Paul Savage
Dr. Paul Savage is a seasoned ER and trauma physician who transformed his career by embracing the health and wellness field of medicine. At 36, he faced a personal health crisis while working at one of the world’s largest trauma centers. Severely overweight, smoking, pre-diabetic, and chronically stressed, he realized that traditional medicine alone could not provide the answers he needed.
His relentless curiosity led him to explore hormonal therapies, integrative treatments, and lifestyle interventions that ultimately transformed his health. This personal evolution inspired him to challenge traditional healthcare practices and create companies and technologies that empower patients to take control of their well-being.
Dr. Savage founded MDLifespan to pioneer advanced methods of strengthening immune systems and removing contaminants from the body. He developed the patent-pending PlasmaXchange™ TPE protocols to address contaminants in the body by combining therapeutic plasma exchange with patient education, advanced diagnostics, and personalized therapies.
