In Episode 03, Dr. Paul Savage joins host Joe Fier for an in-depth look at what Therapeutic Plasma Exchange (TPE) truly is—and why it’s often called an “oil change for humans.” Dr. Savage breaks down the science behind plasma exchange, shares the history of this life-changing procedure, and explains how it’s used today to remove toxins, inflammatory molecules, and even chronic disease triggers from the body.
Dr. Savage recounts the surprising history behind plasma exchange, tracing its roots from ancient practices like bleeding and leech therapy, to the development of medical plasma exchange in the 20th century. He explains how early doctors realized that filtering plasma from the blood could remove harmful antibodies—and how this breakthrough led to machines modeled after dairy cream separators.
Think of plasma exchange as an oil change for your whole body. Blood is removed, plasma (the liquid component) is separated and discarded, and your blood cells are returned to you in a clean, albumin solution. This process removes toxins, inflammatory markers, and other harmful compounds that build up in plasma over time. Within 24 hours, your body manufactures new, toxin-free plasma.
Plasma exchange is well-tolerated and has a long track record of safety. Dr. Savage discusses its use for:
He also covers safety considerations, mild possible side effects, and why special training ensures comfort during the process.
Dr. Savage shares how his decades of experience led to the realization that plasma exchange is uniquely effective for removing the thousands of environmental toxins modern life throws at us. Unlike traditional detox protocols (which struggled as toxin loads increased over the years), TPE reliably and significantly lowers toxic burdens—helping patients feel better, faster.
Each plasma exchange session lasts around four hours, with skilled nurses using ultrasound for precise needle placement. The process is customized for every body size, and most patients report easy recovery—even if “Herxheimer” or detox reactions occur.
Dr. Savage highlights how nearly every patient’s toxin levels drop (often dramatically) after plasma exchange, according to ongoing data at MDLifespan. He emphasizes the need for avoidance strategies but notes that TPE now offers hope against previously “untreatable” toxins, like PFAs and microplastics.
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