We understand why people have questions after seeing recent articles and videos about Therapeutic Plasma Exchange (TPE).
A Message from Dr. Paul Savage and the MDLifespan Advisory Board on Therapeutic Plasma Exchange (TPE)
June 3, 2026
Written By: 
Dr. Paul Savage
A Message from Dr. Paul Savage and the MDLifespan Advisory Board on Therapeutic Plasma Exchange (TPE)
TPE (plasmapheresis) is not a ‘wellness fad.’ It is a long-established, guideline-supported medical procedure that has been used for decades in hospitals and specialty medicine for serious neurologic, autoimmune, hematologic, and inflammatory conditions.
At the same time, it’s important to be honest and precise:
• TPE is a real medical procedure with real risks
• It should only be performed by qualified medical professionals
• Claims around ‘detox,’ anti-aging, or longevity should not be oversimplified
• It should only be performed by qualified medical professionals
• Claims around ‘detox,’ anti-aging, or longevity should not be oversimplified
What is scientifically established is the mechanism itself: plasma exchange removes and replaces a portion of plasma — meaning substances circulating in plasma may also be reduced during the process.
We believe patients deserve balanced, medically grounded information — not hype or fear.
For more information about MDLifespan’s physician-led approach to Advanced Serial Therapeutic Plasma Exchange, please visit www.mdlifespan.com.
To read the formal statement written by Dr. Paul Savage and the MDLifespan Advisory Board Physicians – Read Here
Dr. Paul Savage, founder and Chief Medical Officer of MDLifespan, is a pioneer in personalized medicine and toxin reduction. He developed the patent-pending PlasmaXchange™ protocols to address the global toxin crisis by combining therapeutic plasma exchange with patient education, advanced diagnostics, and personalized therapies. A former ER physician who transformed his own health through integrative and lifestyle medicine, Dr. Savage has dedicated his career to revolutionizing healthcare by making regenerative therapies accessible and scalable. Dr. Savage is the founder of BodyLogicMD, host and producer of The TPE Blueprint podcast, and a contributing author to Suzanne Somers’ Ageless. His work has been published in ScienceDirect. As a keynote speaker and educator, he champions toxin elimination, hormone optimization, and longevity medicine.