Our Story

In 2022, Dr. Paul Savage sold his age management practice, retired, and moved to Brazil. But retirement didn’t last long. A groundbreaking study on the potential of TPE to slow aging processes reignited Dr. Savage’s passion for innovation. The study, a double-blind, placebo-controlled trial exploring TPE’s role in health rejuvenation, was a revelation — the “Aha” moment that brought him out of retirement with a renewed sense of purpose.

Dr. Savage realized this was his calling. With decades of medical breakthroughs under his belt, including pioneering hormone therapy in the early 2000s and age management solutions, he saw an opportunity to take health optimization to a new level. Joined by visionary physicians like Dr. Pamela Smith, he dedicated the last several years to advancing the use of data, disease tracking, and detection in personalized medicine to create a revolutionary approach to detoxification.

This journey culminated in the creation of PlasmaXchange, a patent-pending protocol that uses TPE in ways never before possible to truly detoxify the body. While TPE has been utilized in clinical settings for nearly 50 years to address medical conditions, Dr. Savage and his team reimagined its potential. They developed new use cases for modern health, focusing on removing the environmental toxins that burden the body and prevent optimal wellness.

Dr. Savage calls PlasmaXchange the pinnacle of his career — a fusion of his experience in groundbreaking medical innovations and his vision for the future of health. MDLifespan now stands at the forefront of personalized medicine, offering transformative solutions to address one of the greatest health challenges of our time.

Environmental toxins now represent one of the greatest threats to human health. The World Health Organization identifies toxins as the leading cause of death globally, contributing to chronic inflammation and diseases that undermine human vitality. Dr. Savage explains, “We are living in an era where toxin exposure has escalated dramatically, doubling every decade for the past 60 years. The health impact is unprecedented.”

The PlasmaXchange Protocol offers a proactive response to this crisis. Preliminary findings suggest it significantly reduces microplastic levels and other toxins within six months, helping restore the body’s ability to heal naturally. By focusing on what needs to be removed — not just what can be added — MDLifespan provides a comprehensive path to health and longevity.

Dr. Savage brings over 35 years of medical experience to MDLifespan, drawing on a career dedicated to advancing patient care. The PlasmaXchange Protocol builds on this legacy, offering an innovative approach to detoxification and health preservation.

Described as an “oil change for humans,” this patent pending solution clears out harmful substances, allowing the body to regenerate and thrive.

In 2023 and 2024, MDLifespan has empowered patients with the PlasmaXchange protocol. Performing over 300 TPE procedures combined with proprietary blend IV nutrient therapy, daily supplement powder, and regenerative therapies reporting promising results. Today, the company is expanding nationwide through a select network of providers, making these innovative therapies more widely available.

As a Public Benefit Corporation, MDLifespan remains deeply committed to its mission: creating innovative solutions to eliminate environmental toxins, reduce illness, and enhance quality of life. By prioritizing accessibility and sustainability, MDLifespan ensures that its work benefits not only its patients but also society at large.

At MDLifespan, we are committed to empowering individuals to protect their health and reclaim vitality in a world increasingly burdened by toxins. PlasmaXchange represents a new frontier in health optimization, giving you the tools to thrive in the face of today’s challenges.

Our mission is to develop and deliver to the public innovative methods to eliminate environmental toxins from the human body, reducing illness and disease, enhancing quality of life, and raising awareness about the existential threat toxins pose to humanity.

“It’s not about what you put into the body, it’s about what you take out.” Dr. Paul Savage