What’s the Difference Between PlasmaXchange, TPE, and EBOO?

If you’ve been searching for answers on “EBOO vs. TPE” or “which detox therapy is right for me?”—you’re not alone. These terms are trending in the world of regenerative health. And while Therapeutic Plasma Exchange (TPE) and Extracorporeal Blood Oxygenation and Ozonation (EBOO) each offer powerful benefits, MDLifespan’s patent-pending PlasmaXchange Protocol is redefining the category entirely. 

Here’s how they compare—and why more people are turning to MDLifespan for a complete, science-backed detox solution. 

Known as an “oil change for the body”, PlasmaXchange Protocol is a physician-led, patent-pending detoxification and health optimization solution offered by MDLifespan. PlasmaXchange is designed to reduce toxins levels and reverse chronic  inflammation. PlasmaXchnage reduces inflammatory proteins, heavy metals, environmental toxins, pesticides and forever chemicals. Compared to standard detox therapies, it delivers measurable and lasting health improvements. 

The protocol combines: 

• Therapeutic Plasma Exchange (TPE) 

• Advanced diagnostics based on specific health concerns 

• IV nutrient infusions and regenerative cellular support 

• Ongoing lifestyle coaching and re-toxification prevention 

• Data-driven health tracking through the MDLifespan app- coming soon!  

This comprehensive, system-based approach is why it’s currently patent-pending—and why patients see such profound results. 

PlasmaXchange goes beyond traditional TPE by focusing on three core pillars: 

• Data: Advanced diagnostics to measure toxin levels and track biomarker improvements. 

• Disease: Targeting the root causes of chronic inflammation linked to toxin buildup. 

• Decision: Personalized protocols to identify and remove what’s making you worse. 

This data – driven approach doesn’t just help remove toxins — it provides measurable progress, giving you the tools to reclaim your health and achieve optimal wellness. 

MDLifespan offers eight distinct PlasmaXchange Protocols, each addressing specific health goals: 

• MDL Brain Protocol: Supports cognitive clarity by reducing inflammation and toxins associated with brain fog and memory decline. 

• MDL Heart Protocol: Optimizes cardiovascular health by clearing harmful inflammatory proteins and improving circulation. 

• MDL Toxin Protocol: Reduce toxic metals, environmental toxins, microplastics, and more from your system 

• MDL Cancer Protocol: Designed to strengthen immune defenses and remove toxins that may contribute to cancer progression. 

• MDL Immunity Protocol: Helps reset the immune system, reduce inflammation, and increase resilience to autoimmune stressors. 

• MDL Longevity Protocol: Aims to slow biological aging and improve energy, cellular repair, and organ function. 

• MDL Baby Protocol: Planning for a healthy pregnancy to reduce toxic load and promote hormonal and reproductive health. 

• Dr. Jill’s MDL Mold Protocol: a comprehensive approach to address chronic mold toxicity and associated health issues. 

Learn more about these options on our PlasmaXchange Protocols comparison page. 

TPE is a minimally invasive medical procedure that removes the plasma—the liquid part of your blood—and replaces it with a sterile, albumin-based solution. This acts like a mini “oil change,” flushing out inflammatory proteins, heavy metals, and environmental toxins. 

Key Benefits of TPE: 

• May remove some toxins like BPA, lead, glyphosate, and PFAS 

• Supports immune balance and reduces inflammation 

• Enhances cellular function and organ support 

However, most clinics offering TPE do not include diagnostics, nutritional support, or personalized health optimization. 

MDLifespan’s PlasmaXchange includes Therapeutic Plasma Exchange (TPE).  

What sets PlasmaXchange apart from traditional TPE? 

Personalized Medicine: PlasmaXchange combines TPE with a personalized health optimization plan. This includes nutrient IVs, lifestyle adjustments, regenerative wellness, and supplements tailored to your specific needs. 

Sustained Benefits: A maintenance plan helps prevent toxin buildup, supporting long-term health and well-being. 

For a deeper dive, visit our TPE Overview. 

Reviewed by Dr. Muhammad Mansour, MS, ND 

EBOO filters blood and exposes it to medical-grade ozone. This process produces ozonides, which may: 

• Kill pathogens and stimulate antioxidant pathways (e.g., cytochrome P450 enzymes) 

• Improve oxygen utilization by mitochondria 

• Reduce clotting/coagulation by improving blood viscosity 

• Cross the blood-brain barrier, leading to effects that may last weeks to months 

Reported Benefits: 

• Temporary immune boost and modulation (Th1/Th2 balance) 

• Support in chronic infections (e.g., tickborne/Lyme) and acute viral illnesses 

• Improved oxygenation and tissue perfusion (beneficial in ischemic conditions, post-stroke) 

• Enhanced mitochondrial function and NAD+ levels 

• Potential antimicrobial and antiviral properties (e.g., Herpes family, Ebola, Hepatitis C) 

• Possible reduction in certain high molecular-weight toxins (e.g., beta-2 microglobulin) and microplastics (based on preliminary CTA filter data) 

Important Considerations: 

• EBOO does not physically remove plasma-bound toxins as PlasmaXchange and TPE do 

• EBOO equipment and filters vary—only the CTA (Cellulose Triacetate) filter by Kawasumi, Japan is ozone-resistant and validated 

• Not suitable for everyone (e.g., mast cell activation, chemical sensitivities) 

• G6PD status and oxidative stress markers should be tested beforehand to avoid complications such as hemolysis 

To learn more, visit  https://aaot.us/page/Literature 

MDLifespan’s PlasmaXchange Protocol takes the power of TPE and enhances it with: 

• Personalization by medical condition (Brain, Heart, Immunity, Baby, etc.) 

• Long-term wellness strategies 

• Advanced testing and targeted IV therapy 

What the Data Shows: 

• Up to 100% reduction in heavy metals

• Up to 90% reduction in microplastics, pesticides, forever chemicals

• Up to 95% improvement in inflammatory biomarkers

PlasmaXchange is designed to remove a wide range of harmful chemicals and toxins that accumulate in the body over time. These include: 

• Heavy Metals: Such as aluminum, mercury, lead, and arsenic, which can damage organs and disrupt cellular function. 

• Plastics and Phthalates: Including BPA (Bisphenol A) and MEOHP (a phthalate metabolite), which are hormone disruptors found in plastics and personal care products. 

• Pesticides and Herbicides: Such as glyphosate (commonly found in Roundup), which is linked to inflammation and chronic diseases. 

• Forever Chemicals (PFAS): These are persistent environmental toxins found in non-stick cookware, water-resistant fabrics, and more. PlasmaXchange has shown promising results in reducing these. 

• Mycotoxins: Toxins produced by mold, which are notoriously difficult to remove through conventional detox methods. 

• Inflammatory Proteins: These drive chronic inflammation and are linked to autoimmune conditions and cardiovascular issues. 

• Oxidative Stress Markers: Compounds that contribute to cellular damage and aging . 

The protocol achieves reductions of up to 99% in certain toxins, with long-lasting effects even six months post-treatment . 

“Plasma exchange directly removes toxins and inflammatory proteins, reducing inflammation and significantly improving immune resilience. Our comprehensive approach results in sustained, measurable health improvements.” — Dr. Paul Savage, Founder of MDLifespan 

If your goal is deep, measurable detoxification, improved brain function, enhanced cardiovascular health, or preconception preparation, PlasmaXchange Protocol is the most robust and results-driven solution on the market. 

Unlike TPE and EBOO, it is designed as a holistic approach to toxin removal and avoidance, and overall vitality.  

Explore which protocol is right for you on our comparison page. 

If you’re serious about removing toxins, boosting resilience, and reclaiming your health, MDLifespan’s PlasmaXchange Protocol is the future of wellness. 

Schedule a Free consultation and find out how PlasmaXchange can help you feel younger, clearer, and more vibrant.