The genetic theory of aging states that lifespan is primarily determined by the genes we inherit. According to the theory, our longevity is determined mainly at conception and largely depends on our parents and their genes.
Genetics, particularly genetic instability, is a significant contributor to aging. We inherit our parents’ genes, which endow us with traits that will shape our lives. Understanding your genes gives you the ability to take control of your future, and it allows you to make decisions that align with your goals and desires.
Genetic instability is when a gene or genes are not expressed as they should be. Genetic mutations can cause genetic instability. These genetic mutations are caused by viruses, toxins, radiation, oxidative stress, trauma, and most commonly from repeated cell division over time, aka LIFE! This leads to decreased stability over time and increases the risk of developing age-related diseases such as cancer, Alzheimer’s, Parkinson’s, stroke, and heart disease.
As time passes and we age, our bodies accumulate toxins, radiation, and viruses which destabilizes DNA. When this occurs, predetermined areas of the chain may be damaged, particularly those controlling programmed cell death or other vital pathways. Without these controls, cells can evade death and become immortalized, or they enter senescence, a perpetual resting state.
Aging cells also accumulate damage to their mitochondrial DNA, leading to decreased energy output and an inability to generate ATP properly. This decrease in energy output from the mitochondria can then place pressure on the cell’s ability to cultivate new cells, thus leading to the further deterioration of aging tissue.
The cell’s essence, DNA, has ‘tags’ at the end called telomeres. With each replication of the cellular material, one tag is lost – and when no tags are left? Well, that signals to the cell that it is out of time, as without them, these replications become impossible, and the cell dies.
When we view genetics from the view of Longevity, we are looking at essentially three things:
Telomere length determination can tell you how old your DNA is. If any telomeres are shortened, our medical professionals will investigate the cause and provide proven therapies to lengthen or at least slow down this deterioration in your telomere length.
Senescent, or “zombie” cells are not as dormant as previously assumed – they remain alert and can influence neighboring healthy cells into becoming zombies too. When a substantial amount of these zombie cells accumulate, it increases your risk of developing cancer for that specific tissue. Researchers strive to create treatments to recognize and combat this issue by destroying senescent cells.
At this stage, genetic therapy is still limited in medicine. We can detect genes, extend telomeres, and suppress senescent cells. Testing for these fundamental components is essential to give an answer with minimal risk yet maximum benefit.
In the future, these treatments may become more elaborate and specialized to individual situations. The scientific community continually works towards this goal, with innovative clinical trials and research being conducted in many countries worldwide. We will bring you every new therapy backed by scientific evidence.
Genetic instability treatments are only beginning to develop, but they offer great hope and promise for those affected. By understanding the complexities of genetics, we can make real progress toward a healthier, longer life for everyone.
When looking for Genetics, look to the testing! Three essential genetic tests for aging use the following molecular biomarkers – DNA sequencing, telomere length, and senescence cell biomarkers of SA-β-galactosidase and p16. Testing for your genetic code gives us the list of diseases you carry as the seed of your destruction. Measuring the length of the telomeres gives us the biological age of your DNA and provides insights into what may need to be done to improve the telomere length. Measuring SA-β-galactosidase and p16 offers a biomarker for senescence cell elimination, focusing on the harmful effects of these sleeping zombie cells and their influence on neighboring cells.
Our comprehensive method of testing for Genetics:
This testing examines DNA methylation patterns, providing deep insights into the aging process, biological age, and potential health risks. By analyzing these biomarkers, patients and healthcare providers can take actionable steps to optimize longevity and well-being.
Everyone has unique variations in their DNA, known as genetic variants. Specific genetic variants called Single Nucleotide Polymorphisms, or SNPs, can increase the risk of chronic diseases. Our providers can recognize your potential vulnerability to particular illnesses by undergoing a genetic test and developing tailored treatments that will help you best avoid them.
Toxins are a significant threat to our health. Our environment contains toxins in food, air, and water. Our bodies are constantly exposed to these toxins, so we must know how much of each toxin we consume. As we age, our bodies cannot handle these toxins effectively, which can cause serious health problems.
The solution to genetics, including telomeres and senescence cells, lies in accurately measuring those microscopic cellular values. You must identify, neutralize and eliminate!
Our comprehensive Solutions for Genetics:
Detoxification is an essential but often misunderstood and misconstrued process. Despite popular belief associated with trendy "detox" drinks that promise quick results without lasting impact, the real power behind detox stems from making small lifestyle changes to help your body flush out unnecessary toxins for improved health and well-being over time.
You have everything you need inside you to create a healthy, robust, meaningful, and fulfilling life. Life coaching provides an individually designed social and emotional intelligence program with one-on-one support to partner with you on your journey.
Senescence is an aging process in which a cell permanently stops dividing yet does not die. This occurs when the cell experiences various stressors that lead to the accumulation of damaged DNA.
Stem cells possess the extraordinary ability to self-renew and transform into diverse types of cells. However, multiple studies demonstrate that aging has a negative impact on stem cell health; as the cells age, their capacity for regeneration decreases while their potential to become different kinds of cells is impaired.
Toxins are a pervasive danger in our environment, far beyond the traditional scope of heavy metals. Discovering plastics, petroleum products, herbicides, pesticides, and traces of medications and other contaminants in significant quantities inside your body is common.
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The genetic theory of aging states that lifespan is primarily determined by the genes we inherit. According to the theory, our longevity is determined mainly at conception and largely depends on our parents and their genes. This theory states that segments of DNA that occur at the end of chromosomes, called telomeres, determine the maximum lifespan of a cell. Telomeres are at the end of chromosomes, and telomeres become shorter every time a cell divides. These telomeres become shorter and shorter; eventually, the cells cannot divide, and the cell dies.
Aging is a multifactorial process that is determined by genetic and environmental factors. The Human Genome Project demonstrated that 80% of the effect on your genes is the environment, the epigenetics. So, you may have the worst genes possible, but you can alter your fate by optimizing your environment and thereby optimizing your epigenome.
Genetic and environmental factors modulate healthy aging and longevity in humans, and about 20% of human longevity is due to genetic factors. Recently, epigenetic studies have shown that epigenetic modifications, modulated by both genetic background and lifestyle, are extremely sensitive to the aging process and can either be a biomarker of the quality of aging or influence the rate and the quality of aging. Current studies show that interventions changing the interaction between your genes and your environment are essential to determine your chance to attain longevity.
Genetic instability is the increased tendency for DNA mutations and other genetic changes to occur during cell division. These defects may include mutations in particular genes involved in repairing damaged DNA or mistakes not corrected when DNA is copied in a cell. Studying genomic instability may help researchers understand how aging occurs.
Telomeres are the ends of chromosomes, which function as a shield for the DNA’s genetic material. Each time a cell divides, there is a progressive shortening of the telomeres, which leads to a reduction in DNA protection until the cell dies from programmed cell death (apoptosis). So, when you run out of telomeres, you run out of time! For this reason, telomere length can be considered a biological clock, one of the best biomarkers of aging.